Lee University established the Institutional Review Board (IRB) to protect the rights of human participants, to support ethical research with animal subjects, and to promote quality research by faculty and students. Sponsored by the Lee LCA Board.

The IRB must approve any research development, testing, and evaluation designed to develop or contribute to generalizable knowledge concerning living individual(s) about whom an investigator, whether professional or student, conducting research obtains data through intervention or interaction with the individual(s) or identifiable private information. The IRB also reviews and approves any research protocol involving animals.

The IRB committee is made up of 6 individual faculty members representing various departments across campus that perform research with human and/or animal subjects, as well as 1 representative from outside the university.

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